Keep an eye on Intently (1)pentobarbital will decrease the extent or result of benzhydrocodone/acetaminophen by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Warning when discontinuing CYP3A4 inducers that happen to be coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of